

Not any more than palm reading is a science
Well… stick with me here, this is just a devil’s advocate hypothetical.
Your hands are your primary method of interacting with the world. The creases, callouses, and other incidental features are reflections of the ways you most frequently use them.
Obviously you can’t divine the future, but you can gather information about a person. I dare say you could devise experiments to detect correlations between certain features of the hands, and features of the person: their profession, hobbies, grooming habits, clumsiness, etc.
I think a sincere scientific study could identify several hand features with moderately predictive correlations.
Well it’s not just health issues, there’s the arrangement and depth of the creases, callouses, tan lines and stains, cuts and scrapes. If you can map those broadly to character traits (rough and calloused hands imply hard work and industriousness, lots of little injuries imply absent-mindedness, etc), then you can use those character traits to predict the answers to some questions. An absent-minded person is more likely to meet with small misfortunes, for instance.
Combine that with whatever the subject’s questions are, and a bit of basic psychology.