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Yeah this would be possible. You would need to be diligent with backups if you planned on adding mods as the playthrough progresses, as adding mods to an existing save can cause unpredictable behavior.
An easier to manage idea would be to pick a suitable mod pack and play that. I’ve been hosting a Valhelsia 3 server for my friends and I for a couple weeks and it has been a lot of fun. Valhelsia 3 has all the mods you mentioned aside from Ad Astra. Valhelsia 5 has all of them. There are tons of other packs you could play too. I prefer to play packs that are based on 1.16.5 and before as the performance is significantly better than anything that came after.
Oh, you again.