I have a strong feeling they will focus on the battle of Harvest. It would be interesting to see the start of the conflict, the glassing of the planet, and how humans try to figure out of what to do from there and how it ties into Reach/Halo CE.

Chief and Johnson first meet in 2526 in the novel Silent Storm, and CE takes place in 2552, so there is a giant window for them to interact

I’m curious if they will focus on one set of missions or jump around

I am not confident that this will be any good. At all. They have already shown a lot of changes I didn’t ask for and don’t like, I can’t imagine they’re going to suddenly not be a development studio that hates making a Halo game and instead just makes lightly Halo flavored Call of Duty games.